FITC标记的异戊烯基焦磷酸异构酶2抗体
产品名称： FITC标记的异戊烯基焦磷酸异构酶2抗体
英文名称： Anti-IDI2/FITC
产品编号： HZ-15540R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-IDI2/FITC Conjugated antibody
FITC标记的异戊烯基焦磷酸异构酶2抗体
| 英文名称 | Anti-IDI2/FITC |
| 中文名称 | FITC标记的异戊烯基焦磷酸异构酶2抗体 |
| 别 名 | IDI2_HUMAN; Isopentenyl-diphosphate Delta-isomerase 2; Isopentenyl pyrophosphate isomerase 2; IPP isomerase 2; IPPI2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Chicken, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IDI2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IDI2 is a 227 amino acid protein that belongs to the IPP isomerase type 1 family. Localizing to the peroxisome, IDI2 is expressed in skeletal muscle and contains one nudix hydrolase domain. IDI2 utilizes magnesium as a cofactor and participates in isoprenoid biosythesis. IDI2 catalytically converts isopentenyl diphosphate (IPP) to its electrophilic isomer, dimethylallyl diphosphate (DMAPP), a substrate for subsequent reactions that synthesize farnesyl diphosphate and, ultimately, cholesterol. The gene encoding IDI2 maps to human chromosome 10p15.3. Segmental copy-number gains to the IDI2 gene may contribute to the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS). SALS, also known as Lou Gehrig's disease, is a motor neuron disease characterized by neuron degeneration Function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Subcellular Location: Peroxisome. Tissue Specificity: Detected in skeletal muscle. Similarity: Belongs to the IPP isomerase type 1 family. Contains 1 nudix hydrolase domain. Database links: Entrez Gene: 91734 Human Entrez Gene: 320581 Mouse Entrez Gene: 502143 Rat SwissProt: Q9BXS1 Human SwissProt: Q4FZF0 Mouse Unigene: 591325 Human Unigene: 9270 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Idi2是227型氨基酸，属于IPP异构酶1型家族。定位到过氧化物酶体，Idi2在骨骼肌中表达，并含有一个Nudix水解酶结构域。Idi2利用镁作为辅因子参与异丙肾上腺素生物合成。IDI2催化将异戊烯基二***（IPP）转化为其亲电异构体，二甲基烯丙基二***（DMAPP），作为后续反应的底物，合成法尼基二***并最终合成胆固醇。编码Idi2的基因定位于人类染色体10p153。片段拷贝数增加到IDI2基因可能有助于散发性肌萎缩侧索硬化症（SALS）的发病机制。SARS，又称Lou Gehrig病，是一种以神经元变性为特征的运动神经元疾病。