产品名称: FITC标记的紧密连接蛋白23抗体

英文名称: Anti-Claudin 23/FITC

产品编号: HZ--13746R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 :

 Rabbit Anti-Claudin 23/FITC Conjugated antibody



英文名称 Anti-Claudin 23/FITC
中文名称 FITC标记的紧密连接蛋白23抗体
别    名 2310014B08Rik; Claudin23; CLDN 23; CLDN23; CLDNL; CLD23_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Claudin 23
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-23, also known as CLDN23 or CLDNL, is a 292 amino acid multi-pass membrane protein that localizes to cell junctions and belongs to the claudin family. Expressed in stomach and placenta, as well as in germinal center B-cells, claudin-23 is thought to exhibit calcium-dependent cell-adhesion activity through which it plays an essential role in tight junction-specific obliteration of the intercellular space. Human claudin-23 shares 80% sequence similarity with its mouse counterpart, suggesting a conserved role between species. Overexpression of claudin-23 is associated with colon tumors, implicating claudin-23 as a possible metastasis factor.

Subcellular Location:
Integral membrane protein. Tight junctions 

Belongs to the claudin family.

Database links:

Entrez Gene: 137075 Human

Entrez Gene: 71908 Mouse

Omim: 609203 Human

SwissProt: Q96B33 Human

SwissProt: Q9D7D7 Mouse

Unigene: 183617 Human

Unigene: 37817 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

克劳丁超家族由结构相关的蛋白质组成,这些蛋白质是紧密连接的重要结构和功能成分。Claudin-23,又称CLDN23或CLDNL,是一种292个氨基酸的多路膜蛋白,定位于细胞连接,属于Claudin家族。claudin-23在胃、胎盘和生发中心B细胞中均有表达,被认为具有钙依赖性细胞粘附活性,通过该活性,它在细胞间紧密连接特异性封闭中发挥重要作用。人CalDUB-23与小鼠的同源性有80%的序列相似性,表明物种间具有保守的作用。Caltuin 23的过度表达与结肠肿瘤相关,暗示CalDUB-23是可能的转移因子。