FITC标记的溶质载体家族蛋白21成员1C1抗体
产品名称： FITC标记的溶质载体家族蛋白21成员1C1抗体
英文名称： Anti-SLCO1C1/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SLCO1C1/FITC Conjugated antibody
FITC标记的溶质载体家族蛋白21成员1C1抗体
| 产品编号 | bs-11436R-FITC |
| 英文名称 | Anti-SLCO1C1/FITC |
| 中文名称 | FITC标记的溶质载体家族蛋白21成员1C1抗体 |
| 别 名 | OATP-F; OATP1C1; OATPRP5; organic anion transporter F; organic anion transporter polypeptide-related protein 5; organic anion transporting polypeptide 14; SLC21A14; solute carrier family 21 (organic anion transporter), member 14; solute carrier family 21 member 14; solute carrier organic anion transporter family, member 1C1; SO1C1_HUMAN . |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 通道蛋白 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 79kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLCO1C1/OATP-F 401-500aa |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-F is a 712 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-F mediates the Na+-independent, high affinity transport of the thyroid hormones thyroxine (T4) and rT3 and other organic anions. OATP-F is also thought to transport estrone-3-sulfate and sulfobromophthalein (BSP), triiodothyronine (T3) and 17-beta-glucuronosyl estradiol at a much lower efficiency. OATP-F is expressed highly in Leydig cells in testis and in brain. Function: SLCO1C1 is a member of the organic anion transporter family. SLCO1C1 is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants which produce 5 distinct proteins. Subcellular Location: Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus Tissue Specificity: Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels. Similarity: Belongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain. Database links: Entrez Gene: 518047 Cow Entrez Gene: 53919 Human Entrez Gene: 58807 Mouse Entrez Gene: 84511 Rat Omim: 613389 Human SwissProt: Q9NYB5 Human SwissProt: Q9ERB5 Mouse SwissProt: Q9EPZ7 Rat Unigene: 47261 Human Unigene: 284495 Mouse Unigene: 45744 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白质的有机阴离子转运蛋白家族介导肝脏摄取强心苷。OATP F是有机阴离子转运蛋白家族的712氨基酸成员。OATP F是一种多通道膜蛋白，介导甲状腺甲状腺素（T4）、RT3和其他有机阴离子的Na+无关、高亲和力转运。OATP F也被认为能以较低的效率运输3-硫酸雌二醇和磺基溴酞（BSP）、三碘甲状腺原氨酸（T3）和17β-葡萄糖醛酸基雌二醇。OATP F在睾丸和脑内的睾丸间质细胞中高表达。