产品名称: FITC标记的紧密连接蛋白17抗体

英文名称: Anti-Claudin 17/FITC

产品编号: HZ-13751R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 :

 Rabbit Anti-Claudin 17/FITC Conjugated antibody



英文名称 Anti-Claudin 17/FITC
中文名称 FITC标记的紧密连接蛋白17抗体
别    名 CLDN17; CLD17_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  跨膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Claudin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules (JAMs). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge. Mammalian claudin-17 and claudin-8 may be the result of a gene duplication. Claudin-17 is expressed in stratum granulosum of the epidermis and infundibulum and predominantly localizes to the plasma membrane.

Claudin proteins are a family of transmembrane proteins associated with tight junctions, and different tissues exhibit different Claudin composition. There are 18 homolgs present in humans, and mutations in any of these proteins cause a variety of human disease, this indicates their physiological importance. CLDN17, clustered with CLDN8 at human chromosome 21q22.11, is a four transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. 

Subcellular Location:
Integral membrane protein. Tight junctions.

Belongs to the claudin family.

Database links:

Entrez Gene: 26285 Human

Entrez Gene: 239931 Mouse

Omim: 609131 Human

SwissProt: P56750 Human

SwissProt: Q8BXA6 Mouse

Unigene: 258589 Human

Unigene: 126860 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

克劳丁超家族由许多与结构相关的蛋白质组成。这些蛋白质是紧密连接在细胞旁运输中的重要结构和功能组分。在所有紧密连接的组织中,Caldin均位于上皮细胞和内皮细胞中。已知有三类蛋白质定位于紧密连接,包括克劳丁、闭锁素和结合粘附分子(JAM)。由四个跨膜结构域和两个胞外环组成的紧密连接蛋白构成紧密的连接链。新出现的证据表明,克劳丁家族的蛋白质通过区分溶质大小和电荷来调节通过紧密连接的运输。哺乳动物Caldulin 17和CalDUB-8可能是基因复制的结果。Claudin-17在表皮和漏斗的颗粒层中表达,主要定位于质膜。