FITC标记的CoREST3蛋白抗体
产品名称： FITC标记的CoREST3蛋白抗体
英文名称： Anti-CoREST3/FITC
产品编号： HZ-13994R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CoREST3/FITC Conjugated antibody
FITC标记的CoREST3蛋白抗体
| 英文名称 | Anti-CoREST3/FITC |
| 中文名称 | FITC标记的CoREST3蛋白抗体 |
| 别 名 | 4921514E24Rik; C730034D20Rik; E130101E15Rik; FLJ10876; FLJ16298; RCOR3_HUMAN; KIAA1343; MGC28186; OTTHUMP00000035053; RCOR3; REST corepressor 3; RP11-318L16.1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CoREST3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: RCOR2 (REST corepressor 2) and RCOR3 (REST corepressor 3) are nuclear proteins that each contain one ELM2 domain and two SANT domains. RCOR2 and RCOR3, both members of the CoREST family, are thought to function as components of the CoREST complex; possibly playing a role in the transcriptional repression of neuronal genes. Additionally, RCOR2 and RCOR3, in conjunction with CoREST, can form immunocomplexes with a variety of histone-modifying genes, including G9a and HDAC1. Via these protein complexes, RCOR2 and RCOR3 can further regulate transcription by controlling the methylation and demethylation of target genes during early development. While RCOR2 is expressed as only one known isoform, RCOR3 exists as two isoforms due to alternative splicing events. Function: The CoREST3 gene encodes a functional corepressor required for regulation of neural specific gene expression. REST (RE1 silencing transcription factor 1) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long term gene silencing using a distinct functional complex. Silencing of neuronal specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST response elements. Subcellular Location: Nuclear Similarity: Belongs to the CoREST family. Contains 1 ELM2 domain. Contains 2 SANT domains. Database links: Entrez Gene: 55758 Human Entrez Gene: 214742 Mouse Entrez Gene: 684192 Rat SwissProt: Q9P2K3 Human SwissProt: Q6PGA0 Mouse Unigene: 632489 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
RCOR2(REST corepressor 2)和RCOR3(REST corepressor 3)是核蛋白，它们各自包含一个ELM2结构域和两个SANT结构域。RCOR2和RCOR3都是CoREST家族的成员，被认为是CoREST复合体的组成部分，可能在神经元基因的转录抑制中起作用。此外，RCOR2和RCOR3与CoREST结合可以形成具有多种组蛋白修饰基因的免疫复合物，包括G9a和HDAC1。通过这些蛋白复合物，RCOR2和RCOR3可以在早期发育过程中通过控制靶基因的甲基化和去甲基化进一步调节转录。虽然RCOR2仅表达为一种已知的异构体，但RCOR3以TW的形式存在。