Follistatin,卵泡抑素抗体

产品编号HZ-1773R
英文名称Follistatin
中文名称卵泡抑素抗体
别 名Activin binding protein; FS; Follistatin; Activin-binding protein; FS; fst; FST_HUMAN; Human follistatin gene; follistatin isoform FST344 precursor; FST344; follistatin isoform FST317 precursor; FST317; FST_HUMAN.
说 明 书0.1ml 0.2ml
研究领域免疫学 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
Follistatin,卵泡抑素抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Follistatin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Follistatin,卵泡抑素抗体PubMedPubMed
产品介绍background:
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. There is evidence linking polycystic ovary syndrome and follistatin.
Follistatin binds directly to activin and functions as an activin antagonist. It specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone.

Subunit:
Monomer (Potential).

Subcellular Location:
Secreted.

Tissue Specificity:
Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.

Follistatin,卵泡抑素抗体Similarity:
Contains 3 follistatin-like domains.
Contains 3 Kazal-like domains.
Contains 1 TB (TGF-beta binding) domain.

Gene ID:
10468

Database links:
Entrez Gene: 396119 Chicken
Entrez Gene: 327681 Cow
Entrez Gene: 10468 Human
Entrez Gene: 14313 Mouse
Entrez Gene: 445002 Pig
Entrez Gene: 24373 Rat
Omim: 136470 Human
SwissProt: Q90844 Chicken
SwissProt: P50291 Cow
SwissProt: P19883 Human
SwissProt: P47931 Mouse
SwissProt: P10669 Pig
SwissProt: P21674 Rat
Unigene: 9914 Human
Unigene: 4913 Mouse
Unigene: 162557 Rat

Follistatin,卵泡抑素抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

卵泡抑素是一种新发现的生殖调节因子,参与卵巢颗粒细胞分化、黄体形成、卵泡闭锁,胚胎发育及胎盘功能的调节，FST的合成分泌也受垂体促性腺激素、卵巢甾体激素(孕酮)、糖蛋白激素(抑制素、激活素)等多因子调节。