FITC标记的磷酸化丝氨酸/苏氨酸抗体
产品名称： FITC标记的磷酸化丝氨酸/苏氨酸抗体
英文名称： Anti-Phosphoserine/threonine/FITC
产品编号： HZ-11994R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Phosphoserine/threonine/FITC Conjugated antibody
FITC标记的磷酸化丝氨酸/苏氨酸抗体
| 英文名称 | Anti-Phosphoserine/threonine/FITC |
| 中文名称 | FITC标记的磷酸化丝氨酸/苏氨酸抗体 |
| 别 名 | phospho-Ser/Phospho-Thr; pS/pT; p-S/p-T; pSER/pThr; p-SER/p-Thr; p-Sp-T. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Phosphoserine/threonine |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide contain Phosphoserine and Phosphothreonine |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kinases, but also those that are recognized by phosphorylation-dependent binding proteins like 14-3-3. These modular phosphoprotein interacting domains are critical elements in modulating, directing and amplifying intracellular communications. Many critical protein kinases can be regulated by phosphorylation at a specific serine or threonine surrounded by phenylalanine or tyrosine. For example, Akt, an important kinase that regulates cell survival, is activated by phosphorylation at Ser473, a site surrounded by phenylalanine and tyrosine. RSK1, p70 S6 K, and certain PKC isoforms also contain a similar consensus phosphorylation site. Phosphorylation of these sites is required for kinase activity. The Phospho-(Ser/Thr) Phe Antibody is a powerful tool for discovery of new proteins containing this important regulatory motif. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
信号转导途径的特征是靶蛋白中特定序列或基序内丝氨酸和苏氨酸残基的可逆磷酸化。特定的信号转导基序不仅包括由蛋白激酶识别的序列，还包括由磷酸化依赖性结合蛋白如14-3-3识别的序列。这些模块化的磷酸蛋白相互作用域是调节、引导和放大细胞内通信的关键元件。许多关键蛋白激酶可以通过在特定的丝氨酸或苏氨酸上被苯丙氨酸或酪氨酸包围的磷酸化来调节。例如，Akt，一种调节细胞存活的重要激酶，在Ser473被磷酸化激活，该位点被苯丙氨酸和酪氨酸包围。RSK1、p70S6K和某些PKC亚型也含有类似的一致磷酸化位点。这些位点的磷酸化是激酶活性所必需的。磷酸化（SE/THR）PHE抗体是发现包含这种重要调节基序的新蛋白质的有力工具。