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上海信裕生物科技有限公司
ISCU 抗体

ISCU 抗体

商家询价

产品名称： ISCU 抗体

英文名称： ISCU Antibody

产品编号： XY14812-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 ISCU 抗体

Applications
In-house applications ELISA, WB, IHC, IF, IP     Application not tested? Please see our Guarantee.
Published applications WB Publications 2 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human, rat
Images
Prev12NextView more validation data
  • 14812-1-AP;mouse heart tissuemouse heart tissue were subjected to SDS PAGE followed by western blot with 14812-1-AP(ISCU antibody) at dilution of 1:500
  • 14812-1-AP;human lung cancerImmunohistochemical of paraffin-embedded human lung cancer using 14812-1-AP(ISCU antibody) at dilution of 1:50 (under 40x lens)
  • 14812-1-AP;MCF-7Immunofluorescent analysis of MCF-7 cells, using ISCU antibody 14812-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
  • 14812-1-AP;mouse heart tissueIP Result of anti-ISCU (IP:14812-1-AP, 3ug; Detection:14812-1-AP 1:500) with mouse heart tissue lysate 4000ug.
Positive WB detected in Mouse heart tissue, COLO 320 cells, HeLa cells
Positive IP detected in Mouse heart tissue
Positive IHC detected in Human lung cancer tissue, human endometrial cancer tissue
Positive IF detected in MCF-7 cells
Recommended dilution WB : 1:200-1:2000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200
 ISCU 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information ISCU 抗体
Immunogen ISCU fusion protein ag6562 Full name Iron-sulfur cluster scaffold homolog (E. coli)
Calculated molecular
weight		 18 kDa Observed molecular 
weight		 14-15 kDa,18-19 kDa
GenBank accession 
number		 BC061903 Gene ID (NCBI) 23479
Gene symbol ISCU Synonyms 2310020H20Rik, HML, hnifU, ISCU, ISU2, NIFU, NifU like protein, NIFUN
Background

Iron-sulfur (Fe-S) clusters are required for the functions of mitochondrial aconitase, mammalian iron regulatory protein 1, and many other proteins in multiple subcellular compartments. Mitochondrial and cytosolic isoforms of the human Fe-S cluster scaffold protein, iron-sulfur cluster assembly enzyme (ISCU), is involved in activation of iron uptake, redistribution of intracellular iron, and decreased utilization of iron in Fe-S proteins. 
Defects in ISCU gene are the cause of myopathy with exercise intolerance Swedish type (MEIS), which is characterized by lifelong severe exercise intolerance (PMID: 18304497). Two ISCU isoforms ISCU1 (cytosolic, 15 kDa) and ISCU2 (mitochondrial, 18 kDa), were produced by alternative splicing, and ISCU2 is considered the canonical isoform1. ISCU2 protein is rapidly processed upon maturation (PMID: 11060020). Proteintech’s ISCU antibody 14812-1-AP is raised against the full-length ISCU2 and is expected to detect 14 kDa,15 kDa and 18-19 kDa bands which has been reported in the previous observation (PMID: 11060020). ISCU 抗体

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