FITC标记的热休克蛋白105抗体
产品名称： FITC标记的热休克蛋白105抗体
英文名称： Anti-HSP105/FITC
产品编号： HZ-1387R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-HSP105/FITC Conjugated antibody
FITC标记的热休克蛋白105抗体
| 英文名称 | Anti-HSP105/FITC |
| 中文名称 | FITC标记的热休克蛋白105抗体 |
| 别 名 | Antigen NY CO 25; Antigen NY-CO-25; heat shock 105kDa protein; heat shock 105kDa/110kDa protein 1; heat shock 110kDa protein; HS105_HUMAN; Heat shock 105kD alpha; Heat shock 105kD; Heat shock 105kD beta; Heat shock 105kDa protein 1; Heat shock 105kDa protein; Heat shock 105kDa/110kDa protein 1; Heat shock 110kDa protein; Heat shock protein 105 kDa; HSP105; HSP105A; HSP105B; HSP110; HSPH 1; HSPH1; KIAA0201; NY CO 25; Antigen NY CO 25; DKFZp686M05240. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 97kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSP105 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Heat Shock Proteins are ubiquitously expressed in all organisms. They are induced when a cell undergoes various types of environmental stresses like heat, cold and oxygen deprivation. They are characterized by their role as molecular chaperones. Heat shock protein (HSP) 105 exists as two isoforms; alpha and beta which belong to the HSP105/HSP110 protein family. HSP105 acts as both a chaperone to prevent thermal aggregation of proteins and as a regulator of mammalian cells. The HSP105 isoforms are found in the cytoplasm but not in the nucleoli under non-stressed and stressed conditions. Function: Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). Subunit: Interacts with HSPA8/HSC70. Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. Post-translational modifications: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. Similarity: Belongs to the heat shock protein 70 family. Database links: Entrez Gene: 10808 Human Entrez Gene: 15505 Mouse Entrez Gene: 288444 Rat Omim: 610703 Human SwissProt: Q92598 Human SwissProt: Q61699 Mouse SwissProt: Q66HA8 Rat Unigene: 36927 Human Unigene: 270681 Mouse Unigene: 37805 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
热休克蛋白广泛表达于所有生物体中。当细胞经历各种类型的环境压力，如热、冷和缺氧时，它们被诱导。它们的特征在于它们作为分子伴侣的作用。
热休克蛋白（HSP）105作为HSP105/HSP110蛋白家族的两个亚型：α和β。HSP105既起到防止蛋白质热聚集的作用，又起到调节哺乳动物细胞的作用。HSP105亚型在细胞质中发现，但在非应力和应力条件下不在核仁中。