FITC标记的精神障碍相关GAP蛋白抗体
产品名称： FITC标记的精神障碍相关GAP蛋白抗体
英文名称： Anti-srGAP3/FITC
产品编号： HZ-3660R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-srGAP3/FITC Conjugated antibody
FITC标记的精神障碍相关GAP蛋白抗体
| 英文名称 | Anti-srGAP3/FITC |
| 中文名称 | FITC标记的精神障碍相关GAP蛋白抗体 |
| 别 名 | ARHGAP 14; ARHGAP14; Gbi; ME GAP; MEGAP; Mental disorder associated GAP; Rho GTPase activating protein 14; SLIT ROBO Rho GTPase activating protein 3; srGAP 2; srGAP 3; srGAP2; SRGP 2; SRGP2; WAVE associated Rac GTPase activating protein; WRP. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 神经生物学 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 121kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human srGAP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: srGAP3 (SLIT ROBO Rho GTPase-activating protein 3) is a GTPase activating protein (GAP) for the small G protein Rac. It has a putative role in attenuating Rac1 signalling in neurons. srGAP3 is thought to act downstream of the Slit-Robo pathway, which regulates neuronal migration and axonal branching, and play an important role in axonal regeneration after axotomy. It also plays a putative role in severe mental retardation. Subunit: Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG. Tissue Specificity: Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain. Database links: Entrez Gene: 9901 Human Entrez Gene: 259302 Mouse Entrez Gene: 500287 Rat Omim: 606525 Human SwissProt: O43295 Human SwissProt: Q812A2 Mouse Unigene: 654743 Human Unigene: 236401 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
SRGAP3（狭缝Rabo Rho GTP酶激活蛋白3）是小G蛋白RAC的GTP酶激活蛋白（GAP）。它具有减弱神经元RAC1信号转导的作用。SRGAP3被认为是下游的狭缝ROBO通路，它调节神经元的迁移和轴突分支，并在轴索再生后发挥重要作用。它也发挥了重要作用，严重精神发育迟滞。