产品名称: FITC标记的线粒体融合蛋白1抗体

英文名称: Anti-Mitofusin 1/FITC

产品编号: HZ-0557R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: Flow-Cyt=1:50-200

  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 :

 Rabbit Anti-Mitofusin 1/FITC Conjugated antibody



英文名称 Anti-Mitofusin 1/FITC
中文名称 FITC标记的线粒体融合蛋白1抗体
别    名 Mitofusin 1; Fzo homolog; MFN 1; Mitochondrial transmembrane GTPase Fzo 1; Mitochondrial transmembrane GTPase FZO 2; Mitochondrial transmembrane GTPase FZO1B; Mitofusin 1; Mitofusin1; Putative transmembrane GTPase; Transmembrane GTPase MFN1; MFN1_HUMAN; Mitofusin-1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  信号转导  细胞凋亡  新陈代谢  线粒体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse, Rabbit, 
产品应用 Flow-Cyt=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
细胞定位 细胞膜 线粒体
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Mfn 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2.

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.

Forms homomultimers and heteromultimers with MFN2. Multimerization, which is mediated by the second coiled coil region, may play an essential role in mitochondrion fusion. Participates in a high molecular weight multiprotein complex. Interacts with VAT1.

Subcellular Location:
Cytoplasm and Mitochondrion outer membrane.

Tissue Specificity:
Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.

Post-translational modifications:
Ubiquitinated by MARCH5.

Belongs to the mitofusin family.

Database links:

Entrez Gene: 55669 Human

Entrez Gene: 67414 Mouse

Entrez Gene: 192647 Rat

Omim: 608506 Human

SwissProt: Q8IWA4 Human

SwissProt: Q811U4 Mouse

SwissProt: Q8R4Z9 Rat

Unigene: 478383 Human

Unigene: 290414 Mouse

Unigene: 160939 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 


线粒体融合蛋白1(MFN1)和线粒体融合蛋白2(MFN2)是果蝇蛋白Fuzzy洋葱(FZO)的同源物。它们是线粒体膜蛋白,是线粒体融合的中介物。Mfn蛋白功能需要GTPase结构域,但GTPase依赖反应的分子机制以及这两种Mfn蛋白的功能划分尚不清楚。它们对胚胎发育至关重要,并可能在肥胖的病理生物学中起作用。虽然MFN1和MFN2基因被广泛表达,但它们在不同组织中的表达水平不同。心脏中两个Mfn1转录本升高,而Mfn2 mRNA在心脏和肌肉组织中大量表达,但在许多其他组织中仅以低水平表达。Mfn1定位于线粒体并以GTP依赖的方式参与至少两种不同的高分子量蛋白复合物。纯化的重组MFN1具有比MFN2高约八倍的GTP酶活性。