FITC标记的葡萄糖合成酶2抗体
产品名称： FITC标记的葡萄糖合成酶2抗体
英文名称： Anti-Glycogen synthase 2/FITC
产品编号： HZ-3989R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Glycogen synthase 2/FITC Conjugated antibody
FITC标记的葡萄糖合成酶2抗体
| 英文名称 | Anti-Glycogen synthase 2/FITC |
| 中文名称 | FITC标记的葡萄糖合成酶2抗体 |
| 别 名 | Glycogen starch synthase liver; Glycogen starch synthase liver; EC 2.4.1.11; Glycogen synthase 2 liver; GYS2; GYS2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 糖蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Glycogen synthase 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glycogen synthase catalyzes the rate-limiting step in glycogen synthesis. Its activity is regulated by a complex phosphorylation-dephosphorylation mechanism and by allosteric stimulators and inhibitors. Two isozymes of synthase, a skeletal muscle type (Glycogen synthase 1 - GYS1) and a liver type (Glycogen synthase 2 - GYS2), have been identified. Function: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Post-translational modifications: Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity). DISEASE: Defects in GYS2 are the cause of glycogen storage disease type 0 (GSD0) [MIM:240600]; A metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood, high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia. Similarity: Belongs to the glycosyltransferase 3 family. Database links: Entrez Gene: 2998 Human Entrez Gene: 232493 Mouse Entrez Gene: 25623 Rat Omim: 138571 Human SwissProt: P54840 Human SwissProt: Q8VCB3 Mouse SwissProt: P17625 Rat Unigene: 82614 Human Unigene: 275975 Mouse Unigene: 2906 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
糖原合成酶催化糖原合成的限速步骤。其活性受一个复杂的磷酸化去磷酸化机制和变构刺激物和抑制剂调节。已鉴定出两种同工酶：骨骼肌型（糖原合成酶1 -GYS1）和肝型（糖原合成酶2 -GYS2）。