FITC标记的磷酸化β分泌酶抗体
产品名称： FITC标记的磷酸化β分泌酶抗体
英文名称： Anti-phospho-BACE1 (Ser498)/FITC
产品编号： HZ-5215R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-BACE1 (Ser498)/FITC Conjugated antibody
FITC标记的磷酸化β分泌酶抗体
| 英文名称 | Anti-phospho-BACE1 (Ser498)/FITC |
| 中文名称 | FITC标记的磷酸化β分泌酶抗体 |
| 别 名 | BACE1 (phospho-Ser498); BACE1 (phospho-S498); p-BACE1 (Ser498); p-BACE1 (Se498); APP beta secretase; Asp 2; ASP2; Aspartyl protease 2; BACE 1; BACE; Beta secretase 1; Beta secretase; Beta site amyloid beta A4 precursor protein cleaving enzyme; Beta site amyloid precursor protein cleaving enzyme 1; Beta site amyloid precursor protein cleaving enzyme; Beta site APP cleaving enzyme 1; Beta site APP cleaving enzyme; FLJ90568; HSPC104; KIAA1149; Memapsin-2; Memapsin 2; Memapsin2; Membrane associated aspartic protease 2; Transmembrane aspartic proteinase Asp2; BACE1_HUMAN; Beta-secretase 1; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Membrane-associated aspartic protease 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 免疫学 神经生物学 信号转导 转录调节因子 合成与降解 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human BACE1 around the phosphorylation site of Ser498 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]. Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Subunit: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Subcellular Location: Membrane. Tissue Specificity: Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata. Post-translational modifications: Glycosylated. Similarity: Belongs to the peptidase A1 family. Database links: Entrez Gene: 23621 Human Entrez Gene: 23821 Mouse Entrez Gene: 29392 Rat Omim: 604252 Human SwissProt: P56817 Human SwissProt: P56818 Mouse SwissProt: P56819 Rat Unigene: 504003 Human Unigene: 24044 Mouse Unigene: 207201 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
脑沉积淀粉样β肽是阿尔茨海默病的早期和关键特征。淀粉样蛋白β肽是由淀粉样前体蛋白（APP）的蛋白水解裂解产生的两种蛋白酶，其中一种是由该基因编码的蛋白质。编码蛋白，肽酶A1蛋白家族的一员，是I型整合膜糖蛋白和天冬氨酸蛋白酶，主要存在于高尔基体中。该基因已描述了多种编码不同亚型的转录变体。[由RefSeq提供]。