FITC标记的肌球蛋白调节多肽9(平滑肌亚型)抗体
产品名称： FITC标记的肌球蛋白调节多肽9(平滑肌亚型)抗体
英文名称： Anti-MYL9/FITC
产品编号： HZ-2380R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MYL9/FITC Conjugated antibody
FITC标记的肌球蛋白调节多肽9(平滑肌亚型)抗体
| 英文名称 | Anti-MYL9/FITC |
| 中文名称 | FITC标记的肌球蛋白调节多肽9(平滑肌亚型)抗体 |
| 别 名 | MYL9_HUMAN; Myosin regulatory light polypeptide 9; 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; MLC2; MRLC1; MYRL2; Myosin light chain. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MYL9 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MYL9 is the myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. MYL9 protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for MYL9 and the deduced 172-amino acid protein is highly conserved, with only 3 differences between the human and chicken proteins. Light chain phosphorylation causes the folded monomeric form of myosin to extend and assemble into filaments. This observation established the involvement of the MYL9 in conformational transitions of smooth muscle myosin. Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains. Tissue Specificity: Smooth muscle tissues and in some, but not all, nonmuscle cells. Post-translational modifications: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity). Similarity: Contains 3 EF-hand domains. Database links: Entrez Gene: 10398 Human Entrez Gene: 98932 Mouse Entrez Gene: 296313 Rat Omim: 609905 Human SwissProt: P24844 Human SwissProt: Q9CQ19 Mouse SwissProt: Q64122 Rat Unigene: 504687 Human Unigene: 271770 Mouse Unigene: 6870 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MYL9是肌球蛋白轻链，可通过调节肌球蛋白头部的ATP酶活性来调节肌肉收缩。MYL9蛋白结合钙，并被肌球蛋白轻链激酶激活。MyL9发现了两种编码不同亚型的转录变体，推导出的172个氨基酸蛋白是高度保守的，在人和鸡蛋白之间只有3个差异。轻链磷酸化使肌球蛋白的折叠单体形式延伸并组装成细丝。这一观察建立了MYL9参与平滑肌肌球蛋白构象转变的参与。