FITC标记的E3泛素蛋白连接酶dzip3抗体
产品名称： FITC标记的E3泛素蛋白连接酶dzip3抗体
英文名称： Anti-DZIP3/FITC
产品编号： HZ-13044R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DZIP3/FITC Conjugated antibody
FITC标记的E3泛素蛋白连接酶dzip3抗体
| 英文名称 | Anti-DZIP3/FITC |
| 中文名称 | FITC标记的E3泛素蛋白连接酶dzip3抗体 |
| 别 名 | DAZ-interacting protein 3; E3 ubiquitin-protein ligase DZIP3; hRUL138; KIAA0675; RNA-binding ubiquitin ligase of 138 kDa; DZIP3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 表观遗传学 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Recombinant Fragment |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 139kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DZIP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). DZIP3 (DAZ interacting protein 3, zinc finger), also known as UURF2 or hRUL138, is a 1,208 amino acid protein that localizes to the cytoplasm and contains one RING-type zinc finger. Expressed in a variety of tissues with highest expression in heart, skeletal muscle and kidney, DZIP3 functions as an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme, thereby playing a role in signaling events throughout the cell. Multiple isoforms of DZIP3 exist due to alternative splicing events. Function: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. Subunit: Interacts with DAZ proteins. Subcellular Location: Cytoplasm. Tissue Specificity: Widely expressed at low level. Highlyexpressed in skeletal muscle, kidney and heart. Expressed at lowlevel in placenta, lung, brain, liver and pancreas. Similarity: Contains 1 RING-type zinc finger. Database links: UniProtKB/Swiss-Prot: Q86Y13.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
泛素化是三类酶协同作用以靶向短寿命或异常蛋白进行破坏的重要机制。泛素化涉及的三类酶是泛素激活酶(E1s)、泛素结合酶(E2s)和泛素蛋白连接酶(E3s)。DZIP3(DAZ相互作用蛋白3，锌指)，又称UURF2或hRUL138，是一种1208个氨基酸的蛋白质，定位于细胞质中，含有一个环状锌指。DZIP3表达于心脏、骨骼肌和肾脏中表达最高的各种组织中，起E3泛素-蛋白连接酶的作用，该酶从E2泛素结合酶中接受泛素，从而在整个细胞中发挥信号转导作用。由于选择性剪接事件，存在DZIP3的多个异构体。